ESR1 (estrogen receptor 1), estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of the two main types of estrogen receptors, estrogen The receptors are nuclear receptors activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1 (estrogen receptor 1).
Hormone receptor (HR)-positive breast cancers account for approximately 70% of all breast cancers. Endocrine therapy is the main treatment for these patients, but the efficacy is affected by drug resistance. The activation of ligand-independent pathways caused by ESR1 mutation is an important reason for endocrine drug resistance in ER-positive breast cancer.
(includes primer probes only)
Human ESR1 Gene Y537S Mutation Detection Kit (Fluorescent Probe Method)
Human ESR1 Gene D538G Mutation Detection Kit (Fluorescent Probe Method)