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Human KRAS Gene Mutation Detection Kit
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Human KRAS Gene Mutation Detection Kit

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This kit is used to detect KRAS (V-Ki-ras2 Kirsten ratsarcoma viral oncogene homolog) G12D mutation in tissue DNA and cfDNA of plasma samples. The K-ras gene (K-ras, p21) family has three genes associated with human tumors--H-ras, K-ras and N-ras, which are located on chromosomes 11, 12 and 1, respectively. 


The K-ras gene is also known as the p21 gene because it encodes a 21kD ras protein. Of the ras genes, K-Ras, which has the greatest impact on human cancers, acts like a molecular switch: when normal, it controls the pathway that regulates cell growth; when abnormal, it causes the cell to continue growing and prevents the cell from self-destruction. She is involved in intracellular signal transmission. When the K-ras gene is mutated, the gene is permanently activated, and normal ras protein cannot be produced, resulting in disordered intracellular signaling, uncontrolled cell proliferation and cancer. 


About 30% of human malignant tumors are related to RAS gene mutation, and the product of ras mutation can always be in an active state. Mutations in k-ras are common in leukemia, lung, rectal, and pancreatic cancer, with mutations in 30%-35% of rectal cancers. 96% of KRAS gene mutations occur at codons 12 and 13 of exon 2, and KRAS G12D mutations account for about 17-18%.


(includes primer probes only)

Cat No:

Product name

Specification

3.02.01.3096-10

Human KRAS Gene G12D Mutation Detection Kit (Fluorescent Probe Method)

24rxn

3.02.01.3097-10

Human KRAS Gene G12V Mutation Detection Kit (Fluorescent Probe Method)

24rxn

3.02.01.3098-10

Human KRAS Gene G12C Mutation Detection Kit (Fluorescent Probe Method)

24rxn

3.02.01.3099-10

Human KRAS Gene G12A Mutation Detection Kit (Fluorescent Probe Method)

24rxn

3.02.01.3100-10

Human KRAS Gene G12S Mutation Detection Kit (Fluorescent Probe Method)

24rxn

3.02.01.3101-10

Human KRAS Gene G13D Mutation Detection Kit (Fluorescent Probe Method)

24rxn



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