Human NRAS Gene Mutation Detection

The NRAS gene is a GDP/GTP-binding protein, and the more important genes in the same family include KRAS and HRAS. NRAS binds to GTP in an activated state, and binds to GDP in an off state. The mutation of this gene is closely related to melanoma, and the mechanism is that the mutation of this gene leads to the abnormal continuous activation of its downstream genes such as Raf kinase.

The NRAS gene belongs to the Ras oncogene family, which also includes two other genes: HRAS and KRAS. The proteins produced by these three genes are GTPases. These proteins play important roles in cell division, cell differentiation, and cell self-destruction (apoptosis).

(includes primer probes only)